Binding site

 

The active region of a receptor; any site at which a chemical species of interest tends to bind.

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The place on a molecule that a recognizer (protein or macromolecular complex) binds. In this glossary, we will usually consider nucleic acid binding sites. A classic example is the set of binding sites for the bacteriophage lambda repressor (ci) protein on dna (m. Ptashne, how eukaryotic transcriptional activators work, nature, 335, 683-689, 1988). These happen to be the same as the binding sites for the lambda cro protein. (the text mentioned in the figure is sequence logos: a powerful yet simple, tool.)

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