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Dendrimers
are repeatedly branched molecules.
The huge number of papers on dendritic architectures such as dendrimers,
dendronized, hyperbranched and brush-polymers
has generated a vast variety of inconsistent terms and definitions making a
clear and concise unfolding of this topic highly difficult. The purpose of
this section is to provide the vocabulary required for the description of
chemical and physical phenomena as well as application
aspects associated with the research in the area of dendritic molecules.
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A
dendrimer is a tree-like highly branched polymer
molecule (Greek dendra = tree). Dendrimers are
synthesized from monomers
with new branches added in discrete steps ("generation")
to form a tree-like architecture. A high level of synthetic
control is achieved through step-wise reactions
and purifications at each step to control the size, architecture,
functionality and monodispersity. Several different kinds of dendrimers have
been synthesized utilizing different monomers
and some are commercially available. This picture shows a "3rd generation"
polyamidoamine (PAMAM) dendrimer. Dendrimers are of particular interest for
cancer applications
because of their defined and reproducible size, but more importantly, because
it is easy to attach a variety of other molecules
to the surface of a dendrimer. Such molecules
could include tumor-targeting agents (including but not restricted to
monoclonal antibodies), imaging contrast agents to pinpoint
tumors, drug molecules
for delivery to a tumor, and reporter molecules
that might detect if an anticancer drug is working.
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A
dendrimer is a molecule
with a form like the branches of a tree. The name comes from the Greek
dendra, meaning "tree." In 1979, the first dendrimer was
synthesized by D.A. Tomalia and other researchers at the Dow Chemical
Company, and dendrimers have been studied all over the world because their
form is unique.
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Macromolecule built up from a monomer, with new branches added to each existing
branch.
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Synthetic,
three-dimensional macromolecule built up from a monomer, with new branches added in a step-by-step
fashion until a symmetrical branched structure is created
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A
polymer
with multiple branches. Dendrimers are synthetic
3-D macromolecular structures that interact with cells,
enabling scientists to probe, diagnose, treat, or manipulate cells on the nanoscale.
From the Greek word dendra, meaning tree.
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A
dendrimer is an artificially manufactured or synthesized molecule built up from branched units called monomers. Such processes involve working on the
scale of nanometers.
Technically, a dendrimer is a polymer,
which is a large molecule
comprised of many smaller ones linked together.
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A
dendrimer (from Greek dendra for tree) is an artificially manufactured or
synthesized branched molecule
built up from monomers.
Basically, a dendrimer is a polymer
and it's name is derived from "dendritic polymer".
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From
the Greek word dendra - tree, a dendrimer is polymer
that branches. [Encyclopedia Nanotech]
"...a tiny molecular
structure that interacts with cells,
enabling scientists to probe, diagnose, cure or manipulate them on a nanoscale." Invented by Professor Donald
Tomalia from Central Michigan University. [smalltimes] See this article for a
great explanation Dendrimers: Branching out into new realms of molecular architecture.
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Artificial
molecule structure that has tiny branches or sprigs
sprouting from it, which allow it to carry drug molecule
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A
dendrimer is an artificially manufactured or synthesized molecule built up from branched units called monomers. Such processes involve working on the
scale of nanometers.
Technically, a dendrimer is a polymer,
which is a large molecule
comprised of many smaller ones linked together.
Source
|
|
From
the Greek word dendra - tree, a dendrimer is polymer
that branches. [Encyclopedia Nanotech]
"...a tiny molecular
structure that interacts with cells,
enabling scientists to probe, diagnose, cure or manipulate them on a nanoscale." Invented by Professor Donald
Tomalia from Central Michigan University. [smalltimes] See this article for a
great explanation Dendrimers: Branching out into new realms of molecular architecture.
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From
the Greek word dendra - tree, a dendrimer is polymer
that branches.
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From
the Greek word for tree, a polymer
with branching parts invented by Donald Tomalia in the late 1970s. Currently
used in medical research for use as a molecular
"toolkit" for targeted drug delivery.
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A
polymer
in which the atoms
are arranged in many branches and subbranches along a central backbone of carbon atoms.
Also called cascade molecule.
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